生物医学工程学杂志

生物医学工程学杂志

腹主动脉瘤性别差异性的生物力学研究进展

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腹主动脉瘤具有性别差异性,男性发病率较高,而女性破裂与术后死亡率均高,这一性别差异性现象会影响到腹主动脉瘤患者的诊断、治疗及术后康复。本文综述了腹主动脉瘤性别差异性的研究现状,从阈值判定及生物力学、力学生物学等方面探究腹主动脉瘤差异性这一现象,并指出男女腹主动脉尺寸差异、解剖结构及血管结构成分不同而导致的生物力学及力生物学的差异,可能是导致两性腹主动脉瘤呈现出差异性的重要原因。针对腹主动脉瘤性别差异性的生物力学研究,将会为腹主动脉瘤诊断、治疗及器械设计、患者护理和康复提出基于性别差异的改进建议。

The phenomenon of sex differences exists in patients who have abdominal aortic aneurysms (AAA). The occurrence rate of AAA is high in male, while the rates of rupture and postoperative mortality are high for female. This phenomenon of sex differences would affect the diagnosis, treatment and postoperative rehabilitation for AAA patients. This article reviewed the recent research status of sex differences on AAA, and explored the phenomenon of sex differences from the aspects of threshold determination, biomechanics and mechanobiology. This review points out that the sex differences on AAA could ascribe to the differences of biomechanical environment and biological properties induced by the vascular size, anatomy structure and structure components of abdominal aortic artery. The comprehensive investigations of the sex differences on AAA could help to optimize the diagnosis, treatment and device design, patient care and rehabilitation strategy of AAA based on sex differences phenomenon.

关键词: 腹主动脉瘤; 生物力学; 性别差异

Key words: abdominal aortic aneurysm; biomechanics; sex differences

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