生物医学工程学杂志

生物医学工程学杂志

内源性成体神经干细胞神经发生机制的研究进展

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内源性成体神经干细胞的神经发生与大脑正常生理功能以及很多神经退行性疾病息息相关。神经发生受细胞外微环境和胞内信号等因素影响。近几年,已逐步发现了一些具体的影响成体神经干细胞神经发生,包括增殖、分化、成熟、迁移以及与宿主功能整合等方面的信号通路。本文将从细胞外和细胞内两方面总结影响神经分化的信号及其分子机制,包括相关信号通路、神经营养因子、神经递质以及胞内转录因子和表观遗传调控等方面,为通过内源性神经干细胞途径治疗中枢神经系统疾病提供基础理论支持。

Endogenous adult neural stem cells are closely related to the normal physiological functions of the brain and many neurodegenerative diseases. Neurons are affected by factors such as extracellular microenvironment and intracellular signaling. In recent years, some specific signaling pathways have been found that affect the occurrence of neural stem cells in adult neural networks, including proliferation, differentiation, maturation, migration, and integration with host functions. In this paper, we summarize the signals and their molecular mechanisms, including the related signaling pathways, neurotrophic factors, neurotransmitters, intracellular transcription factors and epigenetic regulation of neuronal differentiation from both the extracellular and intracellular aspects, providing basic theoretical support for the treatment of central nervous system diseases through neural stem cells approach.

关键词: 神经干细胞; 神经发生; 分子机制; 分化; 迁移

Key words: neural stem cells; neurogenesis; molecular mechanisms; differentiation; migration

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