为解决鲤鱼脑组织坐标准确定位问题，本文提出一种将鲤鱼脑组织磁共振成像坐标转换为应用脑立体定位仪进行电极植入所需坐标的方法。本研究应用 3.0T 磁共振成像仪对鲤鱼颅脑成像，自主建立颅脑三维立体定位坐标系、颅骨表面辅助三维坐标系和脑组织内部辅助三维坐标系，经两次坐标转换，将脑电极植入位点磁共振图像坐标转换到三维立体定位坐标系中以引导电极植入。实验分 A、B 两组，A 组为磁共振成像仪结合脑立体定位仪组，B 组为脑图谱结合脑立体定位仪组，每组鲤鱼 20 尾（n = 20），分别应用两种方法将电极植入小脑运动区。进行鲤鱼机器人水下实验检验，结果表明 A 组和 B 组植入电极准确度分别为 90% 和 60%，A 组成功率明显高于 B 组（P < 0.05）。故本文的新方法能够准确定位鲤鱼脑组织的坐标。
To solve the problem of precise positioning of carp brain tissue coordinates, it is proposed in this paper for a method for transforming the coordinates of magnetic resonance imaging of carp brain tissue into the coordinates of electrode implantation using a brain stereotaxic apparatus. In this study, the 3.0T magnetic resonance imaging instrument was used to scan the carp brain. We independently established the three-dimensional positioning coordinate system of the brain, the three-dimensional coordinate assistance system of skull surface and the three-dimensional coordinate assistance system in brain tissue. After two coordinate transformations, the magnetic resonance image coordinates of the brain electrodes implantation sites were converted into the three-dimensional stereotactic coordinate system to guide the electrodes implantation. The experimental groups were divided into two groups, A and B. Group A was the group of magnetic resonance imaging apparatus combining with the brain stereotaxic apparatus, and group B was the group of brain atlas combining with the brain stereotaxic apparatus. Each group had 20 tails of carps (n = 20). This two methods were used to implant the electrodes into the cerebellar motor area. The underwater experiments of the carp robots were carried out to test the two methods. The results showed that the accuracy of the implanted electrodes were 90% in group A and 60% in group B. The success rate of group A was significantly higher than that of group B (P < 0.05). Therefore, the new method in this paper can accurately determine the coordinates of carp brain tissue.
引用本文： 彭勇, 王婷婷, 王占秋, 杜丹, 李京龙, 韩晓晓, 刘佳宁, 王爱迪, 周向前. 面向鲤鱼机器人控脑技术的磁共振坐标转换方法研究及应用. 生物医学工程学杂志, 2018, 35(6): 845-851. doi: 10.7507/1001-5515.201807059 复制