生物医学工程学杂志

生物医学工程学杂志

防治肾移植中缺血再灌注损伤的研究进展

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在肾移植中,虽然缺血再灌注损伤(IRI)诱发的非特异性炎症反应会导致移植肾生存能力的下降,但是 IRI 对肾移植远期存活率的影响是不确定的。本文综合回顾分析临床证据和实验室研究结果,以期阐明早期 IRI 与移植肾远期生存能力下降的关系。既往研究分析表明,早期 IRI 可能是通过功能性肾单位减少、移植血管损伤、慢性缺氧以及随后的纤维化等原因导致了移植失败。此外,IRI 也是诱发肾移植功能障碍、急性排斥反应和降低移植器官生存率的重要因素之一。因此,在肾移植中尝试用新的保护方法替代传统方法,或许可以更好地减轻缺血再灌注导致的肾损伤。本文通过综合回顾分析各种防治肾移植中 IRI 的新旧方法,希望可以有助于临床治疗。

During kidney transplant, the non-specific inflammatory response induced by ischemia-reperfusion injury (IRI) will lead to decreased survival ability of transplanted kidney. However, the effect of IRI on long-term survival rate of allograft is not sure. Here we illuminated the relationship between early IRI and decreased long-term survival ability of allograft by retrospectively analyzing the clinical evidences and laboratory investigations. Previous studies showed that early IRI resulted in the graft loss through reduction of renal functional mass, vascular injury, chronic hypoxia and subsequent fibrosis. IRI was also one of the main factors to induce dysfunction of transplanted kidney and acute rejection reaction, and to decrease the allograft survival. Therefore, it’s better to substitute traditional methods with novel measures during kidney transplant which may relieve the renal IRI much better.

关键词: 缺血再灌注损伤; 肾移植; 肾脏保护

Key words: ischemia-reperfusion injury; kidney transplant; renoprotection

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