生物医学工程学杂志

生物医学工程学杂志

高强度聚焦超声脑肿瘤治疗焦域温度均匀分布调控的数值仿真研究

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在高强度聚焦超声(HIFU)脑肿瘤治疗过程中需严格控制治疗温度。本研究通过调控相控换能器激励信号实现了焦域温度均匀分布的目的。首先,本文利用志愿者头部计算机断层扫描(CT)数据和 82 阵元相控换能器建立开颅 HIFU 治疗脑肿瘤的三维数值仿真模型,通过叠加聚焦于两个设定目标点的信号并调控两信号间激励时间差和幅值,研究其对 HIFU 焦域温度分布及焦域形状大小的调控。研究结果表明,两目标点间距离在一定范围内通过调节两激励信号的激励时间差和幅值可以实现焦域内温度均匀分布,同时可调控焦域形状和体积大小。本文研究的仿真结果或可为 HIFU 安全有效地应用于临床治疗提供理论方法和参考。

The temperature during the brain tumor therapy using high-intensity focused ultrasound (HIFU) should be controlled strictly. This research aimed at realizing uniform temperature distribution in the focal region by adjusting driving signals of phased array transducer. The three-dimensional simulation model imitating craniotomy HIFU brain tumor treatment was established based on an 82-element transducer and the computed tomography (CT) data of a volunteer's head was used to calculate and modulate the temperature distributions using the finite difference in time domain (FDTD) method. Two signals which focus at two preset targets with a certain distance were superimposed to emit each transducer element. Then the temperature distribution was modulated by changing the triggering time delay and amplitudes of the two signals. The results showed that when the distance between the two targets was within a certain range, a focal region with uniform temperature distribution could be created. And also the volume of focal region formed by one irradiation could be adjusted. The simulation results would provide theoretical method and reference for HIFU applying in clinical brain tumor treatment safely and effectively.

关键词: 高强度聚焦超声; 平台式温度分布; 焦域调控

Key words: high-intensity focused ultrasound; uniform temperature distribution; focal region modulation

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1. Kennedy J E. High-intensity focused ultrasound in the treatment of solid tumours. Nat Rev Cancer, 2005, 5(4): 321-327.
2. Ter Haar G. Therapeutic applications of ultrasound. Prog Biophys Mol Biol, 2007, 93(1/3): 111-129.
3. Mcdannold N, Clement G T, Black P, et al. Transcranial magnetic resonance imaging-guided focused ultrasound surgery of brain tumors: initial findings in 3 patients. Neurosurgery, 2010, 66(2): 323-332.
4. Elias W J, Huss D, Voss T, et al. A pilot study of focused ultrasound thalamotomy for essential tremor. N Engl J Med, 2013, 369(7): 640-648.
5. Chang W S, Jung H H, Kweon E J, et al. Unilateral magnetic resonance guided focused ultrasound thalamotomy for essential tremor: practices and clinicoradiological outcomes. J Neurol Neurosurg Psychiatry, 2015, 86(3): 257-264.
6. Fry F J. Precision high intensity focusing ultrasonic machines for surgery. Am J Phys Med, 1958, 37(3): 152-156.
7. Fry F J, Kossoff G, Eggleton R C, et al. Threshold ultrasonic dosages for structural changes in the mammalian brain. J Acoust Soc Am, 1970, 48(6b): 1413-1417.
8. Ram Z, Cohen Z R, Harnof S, et al. Magnetic resonance imaging-guided, high-intensity focused ultrasound for brain tumor therapy. Neurosurgery, 2006, 59(5): 949-955.
9. Kohler M O, Mougenot C, Quesson B, et al. Volumetric HIFU ablation under 3D guidance of rapid MRI thermometry. Med Phys, 2009, 36(8): 3521-3535.
10. Partanen A, Tillander M, Yarmolenko P S, et al. Reduction of peak acoustic pressure and shaping of heated region by use of multifoci sonications in MR-guided high-intensity focused ultrasound mediated mild hyperthermia. Med Phys, 2013, 40(1): 013301.
11. Zhou Yufeng. Generation of uniform lesions in high intensity focused ultrasound ablation. Ultrasonics, 2013, 53(2): 495-505.
12. Lee K I, Sim I, Kang G S, et al. Numerical simulation of temperature elevation in soft tissue by high intensity focused ultrasound. Modern Physics Letters B, 2008, 22(11): 803-807.
13. Westervelt P J. Parametric acoustic array. J Acoust Soc Am, 1963, 35(4): 535-537.
14. Hallaj I M, Cleveland R O. FDTD simulation of finite-amplitude pressure and temperature fields for biomedical ultrasound. J Acoust Soc Am, 1999, 105(5): L7-L12.
15. Pennes H H. Analysis of tissue and arterial blood temperatures in the resting human forearm. J Appl Physiol, 1948, 1(2): 93-122.
16. Sapareto S A, Dewey W C. Thermal dose determination in cancer-therapy. Int J Radiat Oncol Biol Phys, 1984, 10(6): 787-800.
17. Ding Xin, Wang Yizhe, Zhang Qian, et al. Modulation of transcranial focusing thermal deposition in nonlinear HIFU brain surgery by numerical simulation. Phys Med Biol, 2015, 60(10): 3975-3998.
18. Pinton G, Aubry J F, Fink M, et al. Effects of nonlinear ultrasound propagation on high intensity brain therapy. Med Phys, 2011, 38(3): 1207-1216.
19. Aubry J F, Tanter M, Pernot M, et al. Experimental demonstration of noninvasive transskull adaptive focusing based on prior computed tomography scans. J Acoust Soc Am, 2003, 113(1): 84-93.
20. Pernot M, Aubry J F, Tanter M, et al. Prediction of the skull overheating during high intensity focused ultrasound transcranial brain therapy//Ultrasonics Symposium, 2004 IEEE, Montreal, Canada, 2004(2): 1005-1008.
21. Ghanouni P, Dobrotwir A, Bazzocchi A A, et al. Magnetic resonance-guided focused ultrasound treatment of extra-abdominal desmoid tumors: a retrospective multicenter study. Eur Radiol, 2017, 27(2): 732-740.
22. Zhang Yanrong, Aubry J F, Zhang Junfeng, et al. Defining the optimal age for focal lesioning in a rat model of transcranial HIFU. Ultrasound in Medicine and Biology, 2015, 41(2): 449-455.
23. Fan X B, Hynynen K. Ultrasound surgery using multiple sonications-treatment time considerations. Ultrasound in Medicine and Biology, 1996, 22(4): 471-482.
24. 陶敏慧. HIFU经颅脑肿瘤治疗焦域的数值仿真研究. 天津: 天津医科大学, 2016.