生物医学工程学杂志

生物医学工程学杂志

注意缺陷多动障碍儿童自发脑活动的多参数静息态功能磁共振研究

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注意缺陷多动障碍(ADHD)儿童的大脑功能异常已经被广泛报道,但是其结果存在不一致性,且半球间功能连接相关研究较少。本研究纳入了 45 名首发未用药 ADHD 儿童和 26 名正常对照儿童,进行静息态功能磁共振扫描。采用局部一致性(ReHo)、度中心性(DC)和镜像同伦功能连接(VMHC)三种测量指标对两组受试的静息态脑活动进行比较分析。发现与正常儿童相比,ADHD 儿童 ReHo 值和 DC 值在右侧额中回区域降低,且两者呈正相关;VMHC 值在双侧枕叶降低,且该改变与 Conners 父母用量表焦虑得分呈负相关,与威斯康星卡片测验正确分类数呈正相关。本研究结果提示了 ADHD 儿童右侧额中回及双侧枕叶自发神经活动的异常。

A great number of studies have demonstrated functional abnormalities in children with attention-deficit/hyperactivity disorder (ADHD), although conflicting results have also been reported. And few studies analyzed homotopic functional connectivity between hemispheres. In this study, resting-state functional magnetic resonance imaging (MRI) data were recorded from 45 medication-naïve ADHD children and 26 healthy controls. The regional homogeneity (ReHo), degree centrality (DC) and voxel-mirrored homotopic connectivity (VMHC) values were compared between the two groups to depict the intrinsic brain activities. We found that ADHD children exhibited significantly lower ReHo and DC values in the right middle frontal gyrus and the two values correlated with each other; moreover, lower VMHC values were found in the bilateral occipital lobes of ADHD children, which was negatively related with anxiety scores of Conners' Parent Rating Scale (CPRS-R) and positively related with completed categories of Wisconsin Card Sorting Test (WCST). Our results might suggest that less spontaneous neuronal activities of the right middle frontal gyrus and the bilateral occipital lobes in ADHD children.

关键词: 注意缺陷多动障碍; 功能磁共振成像; 局部一致性; 度中心性; 镜像同伦功能连接

Key words: attention-deficit/hyperactivity disorder; functional magnetic resonance imaging; regional homogeneity; degree centrality; voxel-mirrored homotopic connectivity

引用本文: 周家秀, 高映雪, 卜暄, 李海龙, 梁艳, 陈宏, 王美豪, 林飞飞, 杨闯, 黄晓琦. 注意缺陷多动障碍儿童自发脑活动的多参数静息态功能磁共振研究. 生物医学工程学杂志, 2018, 35(3): 415-420. doi: 10.7507/1001-5515.201801001 复制

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