生物医学工程学杂志

生物医学工程学杂志

三维打印技术在肝脏外科和肝毒性评价中的研究进展

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三维(3D)打印作为一种新兴的快速成型技术,已广泛应用于生物医学领域。3D 打印最初在医学中主要用于可视化模型、模具的构建,但随着生物医学领域 3D 打印技术的发展,该技术逐渐应用在复杂组织再生和器官重构等方面,通过生物 3D 打印获得的人工组织和器官,有望用于器官移植以及进行新药研发和药物毒性评价等医药学相关的研究。本文重点阐述了 3D 打印技术在肝脏外科中的个体化应用,并重点介绍了生物 3D 打印技术在肝移植、药物肝脏代谢和肝毒性评价中的研究进展,并进一步对其未来发展趋势进行了展望。

Three-dimensional (3D) printing, an emerging rapid prototyping technology, has been widely used in biomedical field. 3D printing was originally used to construct the visualization models and molds in medicine. With the development of 3D printing in biomedical field, the technology was gradually applied in complex tissue regeneration and organ reconstruction. Artificial tissues and organs obtained by 3D printing are expected to be used for organ transplantation, new drug development and drug toxicity evaluation in the field of medicine and health care research. This paper describes the individualized application of 3D printing technology in liver surgery and introduces the research progress of 3D bioprinting technology in liver transplantation, drug metabolism and hepatotoxicity evaluation, and prospects its future development trend to provide a reference for further study.

关键词: 三维打印; 肝移植; 药物代谢; 肝毒性

Key words: three-dimensional printing; liver transplantation; hepatotoxicity; drug metabolism

引用本文: 姚凤, 林蓉. 三维打印技术在肝脏外科和肝毒性评价中的研究进展. 生物医学工程学杂志, 2018, 35(4): 656-660. doi: 10.7507/1001-5515.201710074 复制

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