生物医学工程学杂志

生物医学工程学杂志

难治性抑郁症神经影像研究进展

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抑郁症是常见的精神障碍疾病,其中约 30% 的患者对标准的抗抑郁药物治疗无明显缓解,这种情况被称为难治性抑郁症,其神经生物学机制尚不清楚。神经影像技术可无创探究脑结构、功能和代谢的变化,被逐渐应用于难治性抑郁症的神经生物学机制研究,并发现额叶-边缘系统重要脑区的结构、功能和代谢的异常。本文就难治性抑郁症的神经影像学研究最新进展进行综述,为进一步研究难治性抑郁症的神经生物学机制提供思路及客观影像学依据。

Depression is a common psychiatric disorder, and approximately 30% patients with depression do not respond effectively to standard antidepressant medication; this condition is termed treatment resistant depression (TRD) and its neurobiological mechanism remains unclear. Neuroimaging techniques can non-invasively explore changes in brain structure, function and metabolism. These techniques have been applied in neurobiological research of TRD and revealed critical abnormalities in brain structure, function and metabolism in fronto-limbic system. In this paper, we reviewed the latest progress in neuroimaging researches on TRD, providing new insight and imaging evidence for further neurobiological studies of TRD.

关键词: 难治性抑郁症; 额叶-边缘系统; 脑结构; 脑功能; 脑代谢

Key words: treatment resistant depression; fronto-limbic system; brain structure; brain function; brain metabolism

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1. Otte C, Gold S M, Penninx B W, et al. Major depressive disorder. Nat Rev Dis Primers, 2016, 2: 16065.
2. Lui S, Zhou X J, Sweeney J A, et al. Psychoradiology: The frontier of neuroimaging in psychiatry. Radiology, 2016, 281(2): 357-372.
3. Serra-Blasco M, Portella M J, Gomez-Anson B A, et al. Effects of illness duration and treatment resistance on grey matter abnormalities in major depression. Br J Psychiatry, 2013, 202(6): 434-440.
4. Machino A, Kunisato Y, Matsumoto T, et al. Possible involvement of rumination in gray matter abnormalities in persistent symptoms of major depression: An exploratory magnetic resonance imaging voxel-based morphometry study. J Affect Disord, 2014, 168: 229-235.
5. Abdallah C G, Jackowski A, Sato J R, et al. Prefrontal cortical GABA abnormalities are associated with reduced hippocampal volume in major depressive disorder. Eur Neuropsychopharmacol, 2015, 25(8): 1082-1090.
6. Phillips J L, Batten L A, Tremblay P A, et al. A prospective, longitudinal study of the effect of remission on cortical thickness and hippocampal volume in patients with Treatment-Resistant depression. Int J Neuropsychopharmacol, 2015, 18(8): pyv037.
7. van Eijndhoven P, Mulders P, Kwekkeboom L, et al. Bilateral ECT induces bilateral increases in regional cortical thickness. Transl Psychiatry, 2016, 6(8): e874.
8. Guo Wenbin, Liu Feng, Chen Jindong, et al. Altered white matter integrity of forebrain in treatment-resistant depression: A diffusion tensor imaging study with tract-based spatial statistics. Prog Neuropsychopharmacol Biol Psychiatry, 2012, 38(2): 201-206.
9. de Diego-Adelino J, Pires P, Gomez-Anson B, et al. Microstructural white-matter abnormalities associated with treatment resistance, severity and duration of illness in major depression. Psychol Med, 2014, 44(6): 1171-1182.
10. Peng Hongjun, Zheng Huirong, Ning Yuping, et al. Abnormalities of cortical-limbic-cerebellar white matter networks may contribute to treatment-resistant depression: a diffusion tensor imaging study. BMC Psychiatry, 2013, 13: 72.
11. Murrough J W, Collins K A, Fields J, et al. Regulation of neural responses to emotion perception by ketamine in individuals with treatment-resistant major depressive disorder. Transl Psychiatry, 2015, 5: e509.
12. Johnston B A, Tolomeo S, Gradin V A, et al. Failure of hippocampal deactivation during loss events in treatment-resistant depression. Brain, 2015, 138(Pt 9): 2766-2776.
13. Yamamura T, Okamoto Y, Okada G, et al. Association of thalamic hyperactivity with treatment-resistant depression and poor response in early treatment for major depression: a resting-state fMRI study using fractional amplitude of low-frequency fluctuations. Transl Psychiatry, 2016, 6: e754.
14. Guo W B, Liu F, Xue Z M, et al. Alterations of the amplitude of low-frequency fluctuations in treatment-resistant and treatment-response depression: a resting-state fMRI study. Prog Neuropsychopharmacol Biol Psychiatry, 2012, 37(1): 153-160.
15. Guo W B, Liu F, Chen J D, et al. Abnormal neural activity of brain regions in treatment-resistant and treatment-sensitive major depressive disorder: a resting-state fMRI study. J Psychiatr Res, 2012, 46(10): 1366-1373.
16. Cheng W, Rolls E T, Qiu J, et al. Medial reward and lateral non-reward orbitofrontal cortex circuits change in opposite directions in depression. Brain, 2016, 139(12): 3296-3309.
17. He Zongling, Cui Qian, Zheng Junjie, et al. Frequency-specific alterations in functional connectivity in treatment-resistant and -sensitive major depressive disorder. J Psychiatr Res, 2016, 82: 30-39.
18. Guo Wenbin, Liu Feng, Xue Zhimin, et al. Abnormal resting-state cerebellar-cerebral functional connectivity in treatment-resistant depression and treatment sensitive depression. Prog Neuropsychopharmacol Biol Psychiatry, 2013, 44: 51-57.
19. Lefebvre D, Langevin L M, Jaworska N A, et al. A pilot study of hippocampal N-acetyl-aspartate in youth with treatment resistant major depression. J Affect Disord, 2017, 207: 110-113.
20. Yang Xiaoru, Langevin L M, Jaworska N, et al. Proton spectroscopy study of the dorsolateral prefrontal cortex in youth with familial depression. Psychiatry Clin Neurosci, 2016, 70(7, SI): 269-277.
21. Li C T, Su T P, Wang S J, et al. Prefrontal glucose metabolism in medication-resistant major depression. Br J Psychiatry, 2015, 206(4): 316-323.
22. Peng Wei, Chen Ziqi, Yin Li, et al. Essential brain structural alterations in major depressive disorder: A voxel-wise meta-analysis on first episode, medication-naive patients. J Affect Disord, 2016, 199: 114-123.
23. Gong Qiyong, He Yong. Depression, neuroimaging and connectomics: a selective overview. Biol Psychiatry, 2015, 77(3): 223-235.
24. Zhang Huawei, Chen Ziqi, Jia Zhiyun, et al. Dysfunction of neural circuitry in depressive patients with suicidal behaviors: a review of structural and functional neuroimaging studies. Prog Neuropsychopharmacol Biol Psychiatry, 2014, 53: 61-66.
25. Jia Zhiyun, Wang Yuqing, Huang Xiaoqi, et al. Impaired frontothalamic circuitry in suicidal patients with depression revealed by diffusion tensor imaging at 3.0 T. J Psychiatry Neurosci, 2014, 39(3): 170-177.
26. Baeken C, Marinazzo D, Wu Guorong, et al. Accelerated HF-rTMS in treatment-resistant unipolar depression: Insights from subgenual anterior cingulate functional connectivity. World J Biol Psychiatry, 2014, 15(4): 286-297.
27. Yang Xiaoru, Kirton A, Wilkes T C, et al. Glutamate alterations associated with transcranial magnetic stimulation in youth depression a case series. J ECT, 2014, 30(3): 242-247.
28. 邓佳慧, 李素霞, 董问天, 等. 难治性抑郁症发病机制的研究进展. 中国神经精神疾病杂志, 2014, 40(2): 123-126.